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產品中心 >專題系列 >細胞自噬-LC3質粒/慢病毒/腺病毒 Autophagy-plasmid, adenovirus or lentivirus of LC3 >自噬相關基因
自噬相關基因
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自噬的調控通路

1.        依賴mTOR(哺乳動物雷帕霉素靶點)途徑的自噬

l  PI3K-AKT-mTOR信號通路

l  AMPK-TSC 1/2-mTOR 信號通路

2.        其它的信號通路

l  3-甲基腺嘌呤(3-MA)通過抑制Class ⅢPI3K的活性抑制自噬。

l  beclin1和UVRAG作為正調控子,抗凋亡因子bcl-2作為負調控子共同參與組成ClassⅢPI3 復合物調控自噬。

l  GTP結合的G蛋白亞基Gαi3抑制自噬;GDP結合的Gαi3蛋白活化自噬。

l  死亡相關蛋白激酶(death-associated proteinlinase,DAPK)和DAPK相關蛋白激酶(DAPK-related protein kinase-1,DRP-1)誘導自噬。

l  PKA、casein激酶 Ⅱ、MAP激酶、calcium途徑也在自噬錯綜復雜的調控網格中,但其機制還不甚清楚。

 

貨號

名稱

基因功能描述

Gene ID

載體

規格

價格(元)

GM-LC001

ANXA1

Responsible for Protein Targeting to Membrane;CDS

NM_000700.1

PCDNA3

 1ug

詢價

GM-LC002

ATG3

Responsible for Protein Transport;Involved in Protein Ubiquitination

NM_022488.3

PCDNA3

 1ug

詢價

GM-LC003

ATG4A

Autophagic Vacuole Formation;Responsible for Protein TransportProtease Activity

NM_052936.2

PCDNA3

 1ug

詢價

GM-LC004

ATG4B

Autophagic Vacuole Formation;Responsible for Protein Transport;Protease Activity

NM_013325

PCDNA3

 1ug

詢價

GM-LC005

ATG5

Autophagic Vacuole Formation;Co-Regulators of Autophagy and Apoptosis

NM_001286106

PCDNA3

 1ug

詢價

GM-LC006

ATG7

Responsible for Protein Transport;Involved in Protein Ubiquitination

NM_006395.2

PCDNA3

 1ug

詢價

GM-LC007

ATG10

Responsible for Protein Transport

NM_031482

PCDNA3

 1ug

詢價

GM-LC008

ATG12

Involved in Autophagic Vacuole Formation;Co-Regulators of Autophagy and Apoptosis

NM_004707.2

PCDNA3

 1ug

詢價

GM-LC009

ATG13

Autophagy in Response to Other Intracellular Signals

NM_014741.3

PCDNA3

 1ug

詢價

GM-LC010

ATG14

Autophagy in Response to Other Intracellular Signals

NM_014924.3

PCDNA3

 1ug

詢價

GM-LC011

ATG16L1

Involved in Autophagic Vacuole Formation;Responsible for Protein Transport

NM_030803.6

PCDNA3

 1ug

詢價

GM-LC012

BECN1

Involved in Autophagic Vacuole Formation;Co-Regulators of Autophagy and Apoptosis

NM_003766

PCDNA3

 1ug

詢價

GM-LC013

RB1CC1

NM_014781

PCDNA3

 1ug

詢價

GM-LC014

GABARAPL1

Involved in Autophagic Vacuole Formation

NM_031412.2

PCDNA3

 1ug

詢價

GM-LC015

IRGM

Involved in Autophagic Vacuole Formation

NM_001145805

PCDNA3

 1ug

詢價

GM-LC016

LAMP2

NM_002294.2

PCDNA3

 1ug

詢價

GM-LC017

LC3A

Involved in Autophagic Vacuole Formation

NM_032514.2

PCDNA3

 1ug

詢價

GM-LC018

LC3B

Involved in Autophagic Vacuole Formation

NM_022818.4

PCDNA3

 1ug

詢價

GM-LC019

LRSAM1

NM_138361.5

PCDNA3

 1ug

詢價

GM-LC020

RAB7A

NM_004637.5

PCDNA3

 1ug

詢價

GM-LC021

ULK2

Autophagy in Response to Other Intracellular Signals

NM_014683

PCDNA3

 1ug

詢價

GM-LC022

UVRAG

Autophagy in Response to Other Intracellular Signals

BC064837

PCDNA3

 1ug

詢價

GM-LC023

VPS15(PIK3R4)

Autophagy in Response to Other Intracellular Signals

NM_014602.2

PCDNA3

 1ug

詢價

GM-LC024

VPS34(PIK3C3)

Autophagy in Response to Other Intracellular Signals

NM_002647.2

PCDNA3

 1ug

詢價

 


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